Personally, a difficult aspect of working in a lab was keeping an organized and detailed lab notebook. It does seem like an art and I've seen some really organized notebooks and some not so good notebooks with scribbles lacking dates or experiment labels. I've listed a few things that I've come across: 1. My lab notebook is chronological rather than based on experiments. This causes an issue when running multiple experiments, as parts of experiments become separated with info concerning other experiments. A possible solution would be to have separate notebooks, one for just experiments, another for chronological info/meeting notes/personal thoughts on experiments. 2. I'm never sure how much detail I should put when replicating experiments and using the same procedure. Sometimes I'll re-write the whole procedure, other times I'll just put "refer to procedure on page ##." I've ended up typing up a lot of protocols that I've used and pasting a copy of it at the end of my notebook. For individual experiments that use that protocol, I'll say see ___ protocol, pg ##, and write any modifications to that. 3. My lab notebook is bound and somewhat small, so sometimes gels and stuff have to be cut and paste it into the notebook. There are times, however, when the images won't fit into the notebook, creating another mess....I'll usually just put it into a folder and say see ___ folder. 4. After meeting with my PI, I often come back with multiple sheets of paper. I've been putting that in another separate folder, and usually write the summary of our meeting in my notebook. These loose papers end up stacked in a folder before I end up going through all of them and throwing them out. Do you keep these papers or do you just throw them out later? hmm....I can't think of anything else at the moment, but I thought it might be nice to diverge from admissions talk for a self-improvement discussion. So, what issues have you guys come across when keeping a good lab notebook? any tips/suggestions to keeping an organized and efficient lab notebook?