Thoughts on Nucynta.

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Farmercyst said:
Our pain mgmt guys are starting to write for it quite frequently. I haven't had that class yet, but it sounds intriguing if not promising.
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I have not looked at this in depth yet, but when I originally saw the FDA press release, I questioned how in the world this was different than tramadol......you can tell me what you think (you are intrigued), but I will eventually read for myself and tell everyone how it is.
 
Seizure warning, serotonin syndrome warning, contraindicated with MAO inhibitors, yeah, sounds the same to me...
 
Priapism321 said:
Seizure warning, serotonin syndrome warning, contraindicated with MAO inhibitors, yeah, sounds the same to me...
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So it's more like taking tramadol and like a .3mg of Buprenex at the same time?

We need some heroin addicts up in this to tell us what's up. We need comparative trials.
 
njac said:
www.opiophiles.org is a great resource from the junkies.
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I like drugs-forum.com. If you want to know ANYTHING about the pharmacology, cmax, potentiation of drug effects...those people are on point...I seriously respect their scientific obsession with getting high...
 
Wow...and there we go. A thread on one of the druggie forums about Nucynta.

I'm tellin' ya...this stuff is great, great investigative stuff. It's been almost centuries since we've been able to perform unethical and dangerous experimentation on humans...yet here we have thousands doing it voluntarily. These sites are a gold mine of scientific inquiry.
 
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WVUPharm2007 said:
Wow...and there we go. A thread on one of the druggie forums about Nucynta.

I'm tellin' ya...this stuff is great, great investigative stuff. It's been almost centuries since we've been able to perform unethical and dangerous experimentation on humans...yet here we have thousands doing it voluntarily. These sites are a gold mine of scientific inquiry.
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Holy crap, it's like a parallel dimension of SDN-- the junkie version. @_@
 
WVUPharm2007 said:
Wow...and there we go. A thread on one of the druggie forums about Nucynta.

I'm tellin' ya...this stuff is great, great investigative stuff. It's been almost centuries since we've been able to perform unethical and dangerous experimentation on humans...yet here we have thousands doing it voluntarily. These sites are a gold mine of scientific inquiry.
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Try this one:

http://www.bluelight.ru/vb/showthread.php?t=347068

They were talking it up since 2007!!!

google any drug name add the word bluelight...thses guys seem a little hardcore...def not the average addict...prolly some doper RPh's
 
Don't forget drugbuyers.com!
 
Look ma, it's Tramadol in sheep's clothing......
 
Farmercyst said:
Our pain mgmt guys are starting to write for it quite frequently. I haven't had that class yet, but it sounds intriguing if not promising.
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The Medical Letter will be publishing an issue in mid- Aug regarding Nucynta. (Also check out www.Nucynta.com).
 
Priapism321 said:
Seizure warning, serotonin syndrome warning, contraindicated with MAO inhibitors, yeah, sounds the same to me...
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-- These warnings are class warnings and were not seen in the clinicals for Nucynta (of over 3000 patients).
 
caringperson2 said:
-- These warnings are class warnings and were not seen in the clinicals for Nucynta (of over 3000 patients).
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Class warnings mean we are not dealing with a novel drug, so my argument holds. When I write for an opioid/catecholamine agent, it is generic tramadol. That is it.
 
Old Timer said:
Ryzolt, Ultram whatever....... Please tell me there is a difference......
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UltramER (which has been on the market for 3+yrs) has a different delivery system (for chronic pain) than Ryzolt (which just entered the market this yr). UltramEr delivers the total drug over 24hrs. Ryzolt gives a 50mg spike initially and then the remaining drug over 24hrs. So apples to apples, the Ryzolt patient may have less drug on board toward the end of the 24hrs than then UltramER patient. This drug is a chronic med so why the need to spike the drug ?
 
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metrarx said:
Hot digitty! You write for opioid agents?

Have you ever written yourself a script? Hmmm?

Nah, you're to uptight:meanie:
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I write for whatever I want.....legally.
 
You know, in a "quasi-prescribing, bitch-work" kind of way.....
 
WVUPharm2007 said:
That before the physicians throw quarters at your feet and say "Dance, underling!"
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I am a horrible dancer. Questions and quarters from physicians come very rarely in my real world.
 
caringperson2 said:
UltramER (which has been on the market for 3+yrs) has a different delivery system (for chronic pain) than Ryzolt (which just entered the market this yr). UltramEr delivers the total drug over 24hrs. Ryzolt gives a 50mg spike initially and then the remaining drug over 24hrs. So apples to apples, the Ryzolt patient may have less drug on board toward the end of the 24hrs than then UltramER patient. This drug is a chronic med so why the need to spike the drug ?
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BULL****. In the real world, there are no differences....... Ryzolt is a BS meeeee tooooo drug that drives me insane.....
 
WVUPharm2007 said:
Well, I dance for quarters. I'm a ***** like that. And its a good second income.
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Well, I mean, I guess I would take them if they were bounced my way.....
 
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caringperson2 said:
-- These warnings are class warnings and were not seen in the clinicals for Nucynta (of over 3000 patients).
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Drug rep much?

And now that you mention the clinical trials, the data that you guys have been handing out would not push me towards using this. If you're going to use osteoarthritis for the set of CP patients, it would help if there is a decent difference between Nucynta and placebo.
 
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