Step I Thyroxine and HMG Coa Reductase

[Delacroix22]

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So FA2014 has Insulin and Thyroxine as upregulators of HMG-CoA reductase...

yet Pathoma says hyperthyroidism leads to hypocholesterolemia

and is corroborated by this

http://www.ncbi.nlm.nih.gov/pubmed/3784912

Any one have any insight?

 

[CherryRedDracul]

"Despite the increased activity of the HMG-CoA reductase, levels of TC, LDL-C, ApoB and Lp(a) tend to decrease in patients with clinical or subclinical hyperthyroidism. This is due to increased LDL receptor gene expression resulting in enhanced LDL receptor-mediated catabolism of LDL particles."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109527/

So despite thyroid hormones upregulating HMG-CoA reductase, an upregulation in lipoprotein lipases helps clear all that, hence the hypocholesterolemia.

 

[dyspareunia]

So FA2014 has Insulin and Thyroxine as upregulators of HMG-CoA reductase...

yet Pathoma says hyperthyroidism leads to hypocholesterolemia

and is corroborated by this

http://www.ncbi.nlm.nih.gov/pubmed/3784912

Any one have any insight?

Maybe I'm misreading that study, but...

Cholesterol synthesis, as estimated by HMG-CoA reductase activity, was decreased in the liver of hypothyroid animals. Thyroxine administration, however, significantly increased reductase activity returning it to control levels