TPR FL #1 BS Q45

[sanguinee]

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"Cystic fibrosis is a genetic disease based on the abnormal protein CFTR. If a person with CF receives a double-lung transplant, would the new lungs be expected to develop CF?"

Since it is a genetic disease, wouldn't the abnormal protein CFTR be something that is regulated by transcription/genetics and thus a transplant wouldn't help?
The solution is listed as D because the transplant lung cells "presumably have normal-functioning CFTR and therefore, new lungs should not be subject to the development of CF."

 

[aldol16]

Well, if you get a new lung without the faulty gene, the cells of that new lung are going to keep dividing without the deleterious mutation. So it won't have the abnormal gene. There's no central transcription that occurs in the body - each type of cell replicates basically on its own. That's why you can regrow skin cells easily but not brain cells.

 

[FutureD0C17]

The abnormal protein is transcribed and translated by the cells of the diseased lungs. This DNA has some sort of missense mutation, however, the newly transplanted cells/tissues don't have that problem. Their DNA codes and produces proteins correctly and thus eliminates CF.

 

[aldol16]

This DNA has some sort of missense mutation

It doesn't have to be a missense mutation. In fact, the most common CFTR mutation is a 3-base pair deletion.

 

[sanguinee]

I guess I was over thinking it; thanks guys!