I know lots of people at Mayo. I'm from rochester. I did 2 summers research (published) at Mayo. My parents work at Mayo. About everyone I know works at Mayo. Every pre-med from Rochester knows lots of people at Mayo and has done research/volunteer work at Mayo. I probably have 20 friends who applied to Mayo with this type of connection. I know one who got in (4.0 honors from Duke, 39 MCAT, major research and Volunteer, father chair of a surgical dept. at Mayo), and 1 who got a phone interview. Everybody else pretty much got rejected right off the bat. Thus, it can't possibly be all about who you know. All this having been said, I am not applying to Mayo. Good luck, though.