BOTH Urinary chloride resistant vs chloride responsive question

[Bandwagon1]

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I understand that a chloride responsive metabolic alkalosis is a volume contraction alkalosis and that chloride resistant is not. What I'm a little confused about is that why is Bartter's and Gitleman syndrome a chloride resistant metabolic alkalosis if they deplete the body of volume and basically do the same thing as a diuretic?

 

[Linus van Pelt]

These syndromes cause defects in chloride reabsorption - the chloride you are giving in the saline fluid bolus is just going to be peed out, because it cannot be reabsorbed. That's why it's chloride resistant, even though they may be volume-depleted.