BOTH Urinary chloride resistant vs chloride responsive question

Bandwagon1

5+ Year Member
Jan 25, 2014
28
16
I understand that a chloride responsive metabolic alkalosis is a volume contraction alkalosis and that chloride resistant is not. What I'm a little confused about is that why is Bartter's and Gitleman syndrome a chloride resistant metabolic alkalosis if they deplete the body of volume and basically do the same thing as a diuretic?
 

Linus van Pelt

2+ Year Member
Dec 12, 2014
30
2
Status
Resident [Any Field]
These syndromes cause defects in chloride reabsorption - the chloride you are giving in the saline fluid bolus is just going to be peed out, because it cannot be reabsorbed. That's why it's chloride resistant, even though they may be volume-depleted.