using 2 ER tabs to make an ER dose when OOS

[chicagoboy1984]

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Hi.



If MD ordered bupropion XL 300mg qd and we are OOS, can we change it to XL 150mg and tell pt to take 2 tabs qd? As in…..would there be a PK difference? I know for IR it would be ok, but I wasn’t sure if ER component makes a difference. Thanks.

 

[extra07extra]

I am think is same so ok, ER and XL is same.

 

[croquemonsieur]

I am think is same so ok, ER and XL is same.

What are you playing at? Seriously.

We applied to pharmacy school during the same cycle, so I followed your posts back then. And…you wrote in perfect English. A quick glance at your posts from 2009 confirms this. So why are you choosing to write in broken English now?

 

[zelman]

Usually, it would be fine. There are exceptions. Procardia XL drug info specifically states that 3 x 30mg tabs do not have the same PK as 1 x 90mg.

 

[chicagoboy1984]

Thanks for the reply zelman.

 

[Wheresmyaricept]

The other issue is if the insurance will pay for it...

 

[Wheresmyaricept]

The other issue is if the insurance will pay for it...

 

[Dred Pirate]

we do this in the hospital all the time - there are a few exceptions - although not a tablets - androderm 4mg patch does not equal 2 x 2 mg patches

 

[Sparda29]

We do this in the hospital all the time without any approval from the physician or anything.

 

[zelman]

I think the androderm might be like asacol vs asacol hd. The manufacturer says 2x400 isn't the same as 1x800 because it's a topical product so the is no standard for comparison.