Uworld question on cell mediated vs humoral

[anbuitachi]

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Hi, Uworld had a question about vaccines, which said that killed/viral mainly generate humoral response b/c they can't get inside cells, so they can't get on MHC 1, which is required for significant cell mediated immune response.

I'm a bit confused by this. Doesn't MHC II also activate strong cell mediated immune response..? Since Thelper cells do bind to MHC II.. or are they trying to say that since CD8 T cells wont be doing the killing it doesn't count as a strong cell mediated response? Thank you

 

[Greenbayslacker]

Hi, Uworld had a question about vaccines, which said that killed/viral mainly generate humoral response b/c they can't get inside cells, so they can't get on MHC 1, which is required for significant cell mediated immune response.

I'm a bit confused by this. Doesn't MHC II also activate strong cell mediated immune response..? Since Thelper cells do bind to MHC II.. or are they trying to say that since CD8 T cells wont be doing the killing it doesn't count as a strong cell mediated response? Thank you

Cell-mediated immunity = CD8+ T-cells, macrophages, and cytokines. No antibodies.

CD8+ T-cells are activated via MHC I on all cells (except RBCs).

MHC I are loaded via binding to intracellular degraded proteins (ubiqutin-proteosome pathway).

Killed-virus cannot enter cells -> cannot be degraded and presented on MHC I -> no cell-mediated response.

 

[anbuitachi]

Cell-mediated immunity = CD8+ T-cells, macrophages, and cytokines. No antibodies.

CD8+ T-cells are activated via MHC I on all cells (except RBCs).

MHC I are loaded via binding to intracellular degraded proteins (ubiqutin-proteosome pathway).

Killed-virus cannot enter cells -> cannot be degraded and presented on MHC I -> no cell-mediated response.

hm.. but aren't macrophages activated via T helper cells which is CD4? and Doesn't Thelper cells secrete a ton of cytokines..?