verapamil question

[arda]

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Question is attached.The correct answer is B but i think E is also correct since verapamil decreases contractility and intracellular ca influx.

Any thoughts ?

 

[Apoplexy__]

The key here was to recognize that the action potentials displayed for you are those of nodal pacemaker cells -- NOT cardiac myocytes. Verapamil's effect on these cells is to slow depolarization, not decrease contractility (the cells have minimal contractile function). If you were shown myocyte action potentials, the answer would be decreased contractility.

 

[arda]

wow what a tricky question,thanks 😀

I wish they used dihydropyridine drugs instead of non dihydropyridine drugs like verapamil/diltizem,that would be a much better question in my opinion.