Vraylar
Started by Shikima
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204370lbl.pdf
Looking at the studies now. I'm bored and have an extra hour due to a no-show.
Looking at the studies now. I'm bored and have an extra hour due to a no-show.
Unless I'm missing it, they do not report the results against the active control arms in this release. Also, I'm not sure what the clinically significant difference in the PANSS is. Statistical significance doesn't mean much in clinical trials.
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I worked on this drug back when it was still RGH-188. Makes me miss my consulting days! Was touted to make a splash due to effect on negative and/or cognitive symptoms back then; otherwise similar to other SGAs.
that was several years ago, however...
that was several years ago, however...
I'm waiting for when NMDA drugs will hit the market, as opposed to yet another "me 2" atypical...
Coolest name award. Vraylar makes me feel like I'm slaying real dragons.
Yet another medication to add to the medication merry-go-round that many patient's are put on by providers plumbing beyond their depth.
You should totally name your sword that. Do you have a sword?
Get a sword.
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Yeah, really awesome name. Although sounds a bit like the name of an evil alien overlord.
Wasn't he the one who stole all of our thetans and threw them into a volcano?
True, that was Xenu. Maybe Vraylar was the benevolent alien who tried to save us from losing our thetans.
Whoah now, you're getting into OT III level info there. Have you paid your $100k+ to gain access to that?
Please don't attract Scientologists to this forum. 🙂
This time a D3 partial agonist that helps rats not drown when put into an underwater maze after being given an anticholinergic, therefore it cures negative and cognitive symptoms!
Actually, it's not a 5HT2A antagonist, so it's really a typical antipsychotic (albeit partial agonist at D2), so expect lots of akathisia.
We already know the best things to do in schizophrenia if first treatments don't work well enough. CBT for psychosis, supported employment, family engagement with education on the illness including expressed emotion, etc. Oh yeah, and clozapine.
Amazing that the things that work are hard and/or not profitable. Therefore, I predict Vraylar to be a great success.
This time a D3 partial agonist that helps rats not drown when put into an underwater maze after being given an anticholinergic, therefore it cures negative and cognitive symptoms!
Actually, it's not a 5HT2A antagonist, so it's really a typical antipsychotic (albeit partial agonist at D2), so expect lots of akathisia.
We already know the best things to do in schizophrenia if first treatments don't work well enough. CBT for psychosis, supported employment, family engagement with education on the illness including expressed emotion, etc. Oh yeah, and clozapine.
Amazing that the things that work are hard and/or not profitable. Therefore, I predict Vraylar to be a great success.
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Comes as a +1, +2 or +3 enchantment option.
Yeah, but the prior auth is a mess. You have to have failed Needle, Excalibur, and Narsil.
I wonder if, "Mjolnir" is already patented?
I just searched, and apparently it is the name of an electric sex wand. And now, I'll probably be contacted by the VA IT department questioning my browser search habits.
Vraylar has to be vorpal.
Vraylar, killed 7 in one blow!
"Ask your doctor about Vraylar. He won't know what you're talking about, so it spell it for him. Slowly. Maybe twice if needed. When he looks at you like you're making it up, ask him to Google it and see if it's right for you."
Big if...
I hope the jingle they use to advertise this is as catchy as the one for Latuda... I had that song they played in the commercial with the woman with the dog on the beach in my head for weeks.
With a name that sounds like the nemesis in a Hollywood sci-fi Tom Cruise film, maybe Scientologists will be open to taking it.
The helping with negative symptoms does sound like a pretty big plus in the drug's favour, if it does really work of course. I remember seeing some of my friends who were diagnosed with SZ really struggle with the negative symptoms, even more so it seemed sometimes than the positive ones. Those who did respond well to medication were at least able to get the positive symptoms under control for the most part, if not have them be in complete remission, but the negative symptoms were a different story all together. I know at least one friend was able to manage his negative symptoms (quite well actually) through therapy and having a good support system in place, but for others it was like watching them try to live in this sort of half life, no man's land of existence.
And TV ads for prescription only pharmaceuticals are still so fascinatingly odd for me, which means of course I must now google this Latuda advert of which you speak.
And TV ads for prescription only pharmaceuticals are still so fascinatingly odd for me, which means of course I must now google this Latuda advert of which you speak.
I get hypnotized by this ad that plays all the time for Stelara. It came out in 2014 and is still playing, so it must be working well. It's with a model from one of the model competition reality shows. The first time I saw it I thought it was funny because it's an ad for a psoriasis product but she's covered up through the whole ad— and she makes it look like she's revealing her skin by taking off a coat, but there's a long shirt underneath, and then she just puts on more coats. But over time I've grown to really like the ad. I realized that her poses and clothes are so comical that I never even noticed the side effects. She has a very nice personality and an interesting way of speaking. And the music just makes you feel good:
Edit: Sorry for blowing up the thread with such a large YouTube video. I keep trying to just post the link but it keeps converting to embed itself.
Well she does show her elbows a couple of times...
Excellent. I always need another good miniature hamster name, particularly after unknowingly being gifted a male and female together by a friend...
The one that had to have its own cage because it kept cannibalizing the others was named Vioxx.
The one that had to have its own cage because it kept cannibalizing the others was named Vioxx.
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Hmmm. I had guinea pigs named after Jane Austen characters. But I like it.
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I read that as "hipster name", which given some of the things I've seen tattooed parents call their children around here, it probably isn't far off.
I suppose that's how one gets miniature hipsters, too...
I prefer miniature minotaurs....
