Are there any evidences proving that there is a drug interaction between warfarin and digoxin, if any?
Are there any evidences proving that there is a drug interaction between warfarin and digoxin, if any?
What is an indication that warfarin and digoxin share? If they are used in combination to treat that condition, do you think there's a drug interaction? How about metabolism, are they metabolized via the same pathway?
They may both be used to treat atrial fibrillation. They are both substrates of CYP 3A4, however warfarin is a weak substrate of CYP 3A4, so there is probably not a major interaction, but that is just my opinion with my limited knowledge.
Anyone can feel free to correct me if I am wrong.
Are there any evidences proving that there is a drug interaction between warfarin and digoxin, if any?
Plugging both drugs into the 'Interactions' tab in Micromedex comes up with zero drug-drug interactions.
How sophisticated...
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How sophisticated...
One interaction is that both digoxin and warfrin are highly protein bound drugs so they compete for proteins. If digoxin outcompetes warfaring for the proteins then there is a higher level of free warfarin in the blood and this can increase digoxin's concentrations. This can lead to an increased bleeding time.
Warfarin is highly protein bound, but I don't think digoxin is. The package insert says 25% protein bound. To be classified as "highly", I think you need to be 90-95% protein bound...One interaction is that both digoxin and warfrin are highly protein bound drugs so they compete for proteins.