What are some of the difficulties of filling capsules with pellets?

Aug 25, 2017
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Attending Physician
In many cases, the pellets or granules have a functional coating that controls release. It’s important to verify that the dosing system and the material handling system (product feeder) are not abrading the coating, which could affect the release profile.

Products that comprise a blend of different pellets raise the issue of content uniformity, particularly when the blend includes high- and low-dose pellet groups. The pellets may segregate (de-blend) during feeding or encapsulation. Since many of the modern filling machines can be equipped with more than one pellet feeding system, you can resolve this problem by feeding the pellet products separately.

Can you please suggest what should I do?
 

allantois

5+ Year Member
Jan 27, 2013
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Other Health Professions Student
I don't really understand the question, maybe somebody from pharmacy forum could help
 
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