If you haven't already, you should really read the myEras User Guide. The short answer - once certified/submitted, you can't change your
application, but you can change your profile, documents and list of programs.
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From page 26:
Submitting Your Application
Review your application carefully before certification. The checklist function will alert you when it finds obvious errors, like a missing USMLE ID or application pages that were not completed. The checklist will not notify you if you have misspelled or omitted a word in your application.
Once you have completed your application, you will need to submit it to the ERAS PostOffice for processing. You cannot apply to programs until your application is certified and submitted.
You may only certify and submit your application once!
Once you have submitted your application, you will not be able to make any changes to it or update any information on your MyERAS Application. There are no exceptions. Submitting your MyERAS Application is like placing a written application in the mailbox; you cannot get it back. Be sure your application is complete and correct before submitting.
During certification, graduates of U.S. medical schools who are applying for positions will have to select Yes or No to the question, Do you give your deans office permission to view your application once it has been submitted? This question must be answered to certify and submit your MyERAS Application. Once you certify and submit your MyERAS Application, you will be unable to change your selection. It is recommended that you give your deans office permission to view your MyERAS application, in case you have to participate in Scramble.
Note: The designated deans office for U.S. graduates will be able to view an applicants MyERAS application only after the applicant has released it.
Remember, you may update the information in your Profile at any time. Likewise, you may also update or change your document assignments or add new programs at any time.