Step I what do they mean by centrally?

[realruby2000]

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hey everyone,

I read that small cell and sqaumous cell carcinoma both arise "centrally" wth does that mean? are they saying that it arises in the bronchi/broncioles and not anywhere else? this is screwing me up cuz im having trouble trying to differentiate all the lung cancers

thanks

 

[Mossjoh]

Centrally as in near the origin of the main stem bronchus or one of its early branches

 

[nuclearrabbit77]

they mean closer to the center region of the chest cavity. versus towards the outer aspects seen in adenocarcinomas

 

[optiplex]

centrally = near the hilus of the lung
peripherally = near the pleura, toward the chest wall

 

[babinski bob]

Here's the important Lung tumors to know:

***MOST COMMON LUNG TUMOR = METASTATIC

Non-small cell Ca
1. Squamous cell Ca: centrally located, strongly associated w/ smoking, may produce PTH.
2. Adenocarcinoma: peripherally located, associated w/ young female non-smokers.
3. Bronchioloalveolar carcinoma: peripherally located, occludes lumen
4. Bronchial carcinoid: centrally located, seen in non-smokers, occludes lumen; arises from Kulchitsky cells, a neuroendocrine tumor; pumps out 5-HT --> nausea, vomiting, flushing, diarrhea.

Small-cell Ca
aka oat cell cancer. Centrally located, most strongly associated w/ smoking, arises from Kulchitsky cells; may produce ADH or ACTH; worst prognosis.

Pleural tumors:

Benign mesothelioma: aka pleural fibroma, arises from visceral pleura only, NO relation to asbestos exposure.
Malignant mesothelioma: arises from visceral or parietal pleura, tends to encase lung. Long latent period (25-45y). STrongly associated w/ asbestos exposure, smoking is NOT a risk factor. Microvilli visible on EM.

 

[GiJoe]

hmmm...i just ran into a qbank question today that showed a small cell carcinoma in the right upper lobe... not really central according to some the def. provided.


now im confused

 

[Stinger86]

hmmm...i just ran into a qbank question today that showed a small cell carcinoma in the right upper lobe... not really central according to some the def. provided.


now im confused

That's qbank for you