what makes lysosomes?

[yakuza]

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rough ER or golgi body or both..???

I'm getting diff answers from diff sources

 

[AndyK]

I believe it's both. Digestive enzymes are translated into the cisternae of the rough ER, then a transport vesicle is pinched off and goes to the Golgi. Only a fraction of the total enzymes are present in each transport vesicle, though. So when enough vesicles fuse with the golgi, all the enzymes are concentrated together, and then the lysosome is pinched off of the Golgi and goes to do its thang.

 

[yakuza]

I believe it's both. Digestive enzymes are translated into the cisternae of the rough ER, then a transport vesicle is pinched off and goes to the Golgi. Only a fraction of the total enzymes are present in each transport vesicle, though. So when enough vesicles fuse with the golgi, all the enzymes are concentrated together, and then the lysosome is pinched off of the Golgi and goes to do its thang.

Yeh that's what I was thinking, that the rough ER actually synthesizes it from scratch and then the golgi body does the pinching off thing and makes the actual body of lysosome.

hopefully thats right

any other opinions?
I'll be pissed if I get a question like, what makes lysosomes?
A. Golgi body
B. rough ER
C. only one