What malignancy is assoc. w/CCl4?

[loveoforganic2]

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It's in FA under chemical carcinogens, pathoma mentions it, but all I see is association w/centrilobular hepatic necrosis and fatty change. Didn't find anything in google with a quick search. Is it HCC?

 

[Mcat35]

I tried to look this up in medium robbins since i have already read the chapter, no where does it say that CCl4 directly causes HCC. It is listed under a table for Drug- and toxin induced hepatic injury. As one of the drug/toxin that causes Centrilobular necrosis (others include Bromobenzne, acetaminophen, halothane, rifampin. Other than this baby robbins said that it can cause both liver and kidney damage.

http://www.epa.gov/ttnatw01/hlthef/carbonte.html

no conclusive evidence based on epa

 

[operaman]

Yes it's HCC and by a similar mechanism to alcoholism leading to HCC. The attempted regeneration of hepatocytes that's part of classic cirrhosis --> lots of opportunities for a mutation and neoplastic change.

CCl4 is often used in the lab to induce cirrhosis in test animals and always seems to pop up in the methods sections in papers I read.

 

[loveoforganic2]

Thanks a bunch!