When and why doest Hoffman Elimination occur

[Ramil]

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i looked up other threads but still did not answer my question....
the question of when is ( in what type of reactions? specific names)
The question of where is ( in what type of conditions? ex. solvent, nuc-, leaving group, Temp)

 

[Valigator00]

i looked up other threads but still did not answer my question....
the question of when is ( in what type of reactions? specific names)
The question of where is ( in what type of conditions? ex. solvent, nuc-, leaving group, Temp)

It occurs when bulky base acts as a nucleophile in an elimination reaction.

 

[hausee]

How do you memorize these stuff....😱

It occurs when bulky base acts as a nucleophile in an elimination reaction.

 

[Ramil]

How do you memorize these stuff....😱

Is it strictly E2?
What are some examples of large nuc other than t-butoxide?

 

[Valigator00]

Is it strictly E2?
What are some examples of large nuc other than t-butoxide?

Yes I believe.

 

[sixkiller]

Is it strictly E2?
What are some examples of large nuc other than t-butoxide?

Diisopropylamide will also promote anti-saytseff elimination much like tert-butoxide.

Hofmann elimination is also commonly seen following exhaustive methylation of an amine to yield a quarternary aminium.

The quarternary aminium is treated with silver oxide or silver hydroxide and heat to yield an anti-saytseff eilimination (E2) product.