This is probably a stupid question, but I cannot find an answer online or in textbooks. My attending made it seem like if a patient is breathing on their own they have at least 2/4 TOF ?
I think Pablo is asking because if one equates adequate spontaneous ventilation or adequate ventilation on minimal pressure support settings as being 2(or more)/4 twitches, then you can reverse paralytic without checking twitches. My guess anyway.not a dumb question, but there really isn’t an answer. Too many other variables besides level of neuromuscular blockade go into the patients ability to spontaneously ventilate. Such as narcotic usage, ETCO2, pulmonary status, how sick the patient is, etc.
Maybe your attending meant that if you see at least 2 peripheral twitches then it’s possible to start seeing diaphragm movement. Like if you see 2 or more twitches in the middle of a robotic case it’s probably a good idea to give some more roc before the da Vinci commits murder
ive also seen this when patient has 4/4 twitches. reverse with full dose neo glyc, and still need suggamdex in pacu. i guess thats why they recommend quantitiitaitive tofIve have patients need sugammadex after extubating with good tv on spontaneous ventilation at the end of the case. It is not a reliable measure, just like head lift or whatever
ive also seen this when patient has 4/4 twitches. reverse with full dose neo glyc, and still need suggamdex in pacu. i guess thats why they recommend quantitiitaitive tof
What is full dose neo/glyco?ive also seen this when patient has 4/4 twitches. reverse with full dose neo glyc, and still need suggamdex in pacu. i guess thats why they recommend quantitiitaitive tof
No one knows i agree with you. Probably 2/4, but it's an almost useless number practically anyway. You can't and shouldnt base a clinical decision on this little info aloneThis is probably a stupid question, but I cannot find an answer online or in textbooks. My attending made it seem like if a patient is breathing on their own they have at least 2/4 TOF ?
My practice is to reverse everyone I paralyzed but plan to extubate in the OR. If they're breathing reasonable volumes on PSV 5/5 or 10/5, I'm comfortable that they have something more than 0/4 twitches. But I don't think you can say much more than that. Just reverse them.
most of the ORs i work dont have quantitative monitoring. Some dont even have TOF. I carry my own hand held zapper and use my eyes.I am constantly shocked at the number of ORs I work in where the TOF ratio handpiece is gathering dust since the last time I used it in there months before. None of my colleagues use it, which is substandard.
It's fine to say the equipment may be old and faulty, but not ok to not even put it on. It is an essential monitor any time nmbs are used
What is full dose neo/glyco?
What was their TOF ratio? Was it reliably increasing over time during the case or just a one off?
What was the dose of roc and the timeframes?
How long pre extubation did you give the neo/glyco?
That's a Shame...most of the ORs i work dont have quantitative monitoring. Some dont even have TOF. I carry my own hand held zapper and use my eyes.
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Max dosage of neostigmine is supposed to be 5mg. For the "avg" 100kg patient nowadays does anybody end up using more? Never understood the max dosage part.
We have suggamadex available so I just use that whenever.
Max dosage is because if you use more there's too much acetylcholine and there's overstimulation of the muscarinic receptor a la cholinergic crisis. Not sure if anyone has actually seen it happen but I'm sure it does. I was also taught in residency never to give neostigmine alone to avoid life threatening bradycardia and asystole but I'm not sure that this happens either. I have given neostigmine alone in ogilvies syndrome and the patient didn't die
Stories of more than one patient coding in the ICU after neostigmine for Ogilvie syndrome where I did residency.Max dosage is because if you use more there's too much acetylcholine and there's overstimulation of the muscarinic receptor a la cholinergic crisis. Not sure if anyone has actually seen it happen but I'm sure it does. I was also taught in residency never to give neostigmine alone to avoid life threatening bradycardia and asystole but I'm not sure that this happens either. I have given neostigmine alone in ogilvies syndrome and the patient didn't die
I saw this one time when it was my 1st week in hospital as a medical student, maybe even 1st day. Never heard of Ogilvies or neostigmine or any of that...Did they code brown or just fart?
I can attest to the fact that it does indeed happen.I was also taught in residency never to give neostigmine alone to avoid life threatening bradycardia and asystole but I'm not sure that this happens either.
You mean in the 1970s you saw this? WowI can attest to the fact that it does indeed happen.
Very old school - like 70s - I saw neostigmine or pyridostigmine used to attempt to break PAT/SVT in the ER.
I can attest to the fact that it does indeed happen.
Very old school - like 70s - I saw neostigmine or pyridostigmine used to attempt to break PAT/SVT in the ER.
But that's why you're adding the equivalent dosage of anti-muscarinic agent. I just don't understand weight based dosing with a max.Max dosage is because if you use more there's too much acetylcholine and there's overstimulation of the muscarinic receptor a la cholinergic crisis. Not sure if anyone has actually seen it happen but I'm sure it does. I was also taught in residency never to give neostigmine alone to avoid life threatening bradycardia and asystole but I'm not sure that this happens either. I have given neostigmine alone in ogilvies syndrome and the patient didn't die
But that's why you're adding the equivalent dosage of anti-muscarinic agent. I just don't understand weight based dosing with a max.