Where are memory T and B cells stored?

[Monkeymaniac]

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Once T and B cells differentiate into memory cells, where are they stored? Are they stored in lymphoid nodes or bone marrow? Thanks in advance.

 

[dragoonies]

Once T and B cells differentiate into memory cells, where are they stored? Are they stored in lymphoid nodes or bone marrow? Thanks in advance.

When you think of bone marrow, think of immature blood cells. They leave the bone marrow and float around (periodically moving from lymph node to lymph node) to mature. Only once B-cells encounter their specific antigen do they form clones and memory cells.

 

[Flapjacks]

And once they form memory cells, the question asker wants to know where they are stored.

 

[Monkeymaniac]

Yes, I was wondering where are the differenciated memory cells (B and T) stored.

 

[dragoonies]

For the memory B-cells, I would bet it's still the lymph nodes. They are basically waiting for the Ag to appear again, and the best place to do that is in the lymph nodes. For the memory T-cells it's harder to pin down since tend to move into peripheral tissues. Whatever the case, they will not move back into the bone marrow.

 

[addo]

after maturation, they will reside in the lymph nodes.

 

[Monkeymaniac]

Thank you very much guys.

 

[RogueUnicorn]

When you think of bone marrow, think of immature blood cells. They leave the bone marrow and float around (periodically moving from lymph node to lymph node) to mature. Only once B-cells encounter their specific antigen do they form clones and memory cells.

plasma cells also colonize the marrow... just saying..

 

[badmintondr]

Yup, the bone marrow has both a synthesizing function for synthesizing the blood cells and storing the blood cells. As such it acts as a primary and secondary lymphoid organ. (Side tidbit of information which may help you remember) Primary- makes, secondary-stores