I am going through the match as we speak. I, too, have struggled with the "tier" issue. I know that Mayo Rochester has D.O.s. I know it is not the Ivy League of the Northeast, but I would consider it top tier. I think it depends on what you are looking for in a program. I agree with the notes above that many institutions with huge research resources are looking for M.D.s, and even more than that, it is easier to join them if you have done research. I am trying to decide between Mayo and Duke. Duke has a great name, big research, great reputation. Mayo has a warm feel, beautiful facilities, great mentoring, and all of their psychiatric facilities are in one building. I am not sure what to make of top tier. I am sure that some think that Duke is a better place to train. When I look at the resident biographies, many have been to Harvard, UPenn, Princeton, etc. At Mayo, I see people from everywhere and each class may have a D.O. or two. I don't think that this is because they don't receive as great an applicant pool but rather that they are looking beyond the degree and towards the person. They do identify hard work and love for patients, but the name of your institution matters less when applying. Just work hard, love patients, and opportunities will open up. I am from a really small school that doesn't have a name. I interviewed at Yale and Johns Hopkins, Duke and Columbia, UPenn and NYU. I had a great variety. The only research I did was in college. But, I had great boards and grades. I took on community and leadership activities. They saw those things more than they saw the name of my school. While it is and M.D. school, I don't think that is what mattered. Working hard also gets you great letters of recommendation. Hope this helps, and if anyone has any points on Mayo versus Duke, please let me know!!