Which ARB would you recommend...

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mipharmd

PharmD/M.P.H
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  1. Pharmacist
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Which ARB would you recommend to patients to use if they are using it for renal protection in diabetes if ACE I are intolerable?

I am studying for Naplex and while working as an intern, this question seems to keep coming up since I've seen many patients not take thier ACEI due to coughing...
 
Think it's Telmisartan. Look it up and make sure though. Only sticks out in my mind because of an ACEI/ARB combo trial I read a while back. And from what I remember about Telmisartan, that's what I'd put my money on.

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Why is it always have to be money with you....typical rep!
 
I say losartan.......
 
Really?? Hmmmm...look it up and tell me. Too hard on the Crackberry.

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It is the only one that has the indication for nephropathy I believe......
 
Why is it always have to be money with you....typical rep!

It's not always about $!!! Sometimes just a bet and a good handshake for bragging rights is all you have to put on the line. Which I often lose! 😉

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It's not always about $!!! Sometimes just a bet and a good handshake for bragging rights is all you have to put on the line. Which I often lose! 😉

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A bet for money is goofy. Not only when you lose, you've been proven wrong...then you have to pay up. That's a double whammy. Especially if it's a bet you have no control over.. :meanie:
 
A bet for money is goofy. Not only when you lose, you've been proven wrong...then you have to pay up. That's a double whammy. Especially if it's a bet you have no control over.. :meanie:

Well, I rarely do bet...and I never collect when I win. But I'll pay up.

So what's the answer Pri? There's got to be a class comparison...aside from just one with the indication.

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Think it's Telmisartan. Look it up and make sure though. Only sticks out in my mind because of an ACEI/ARB combo trial I read a while back. And from what I remember about Telmisartan, that's what I'd put my money on.

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I believe you are the grand prize winner. While there is no proof, I think this will turn out to be a class effect....
 
Since when do YOU go with FDA indication? 😉

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Not often....I went with the one that had the indication based on what this guy is studying for. In reality, I don't think the ARB that is selected makes a damn bit a difference. My honest answer is the first one that goes generic is the one I would favor.

What is the rationale behind telmisartan again for this particular NAPLEX question, I am missing something I think?
 
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Not often....I went with the one that had the indication based on what this guy is studying for. In reality, I don't think the ARB that is selected makes a damn bit a difference. My honest answer is the first one that goes generic is the one I would favor.

What is the rationale behind telmisartan again for this particular NAPLEX question, I am missing something I think?

No, I wasn't sure either. But s(he) seemed to be looking for one. Thought I remebered something about it regarding proteinuria?

Like you said...I'm not sure about the validity of the question clinically anyways.
 
Lol...what are you talking about. It's in the OP's question!

Tell me a cough suppressant you'd actually recommend...

I recommend codeine/guaifenesin (largely because I consider guaifenesin an inert compound). $11 a bottle versus most of my medical/pharmacy colleagues' favorite, hydrocodone/chlorpheniramine at $80 a bottle.
 
Should have decent amount of Tc on Monday...boy it's a good feeling! 👍

I talked to a Nucular Druggist who said they didn't rely on Chalk River at all, and he was enjoying taking a lot of his competitors' business......
 
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I talked to a Nucular Druggist who said they didn't rely on Chalk River at all, and he was enjoying taking a lot of his competitors' business......

I could comment, but would be disclosing too much if I did. Could always shoot you a PM if you were really that interested.

Ask him/her how they fared a couple months ago during the last shortage though, when Covidien was screwed.
 
I could comment, but would be disclosing too much if I did. Could always shoot you a PM if you were really that interested.

Ask him/her how they fared a couple months ago during the last shortage though, when Covidien was screwed.


It's dirty business I say!!
 
I could comment, but would be disclosing too much if I did. Could always shoot you a PM if you were really that interested.

Ask him/her how they fared a couple months ago during the last shortage though, when Covidien was screwed.

Haha, I don't want to get you too fired up....it was just a guy I play poker with; I was just making small talk with him, not a detailed discussion by any stretch.
 
Haha, I don't want to get you too fired up....it was just a guy I play poker with; I was just making small talk with him, not a detailed discussion by any stretch.

😛 Don't worry, it takes a lot more than that to get me fired up!!!

It's just an interesting dynamic, the way the system runs. Some pharmacies are under contract to only get generators from one of the two manufacturers. So if/when they go down, they've got nowhere to turn. Some pharmacies on the other hand, are able to get their supply from either supplier...and fare much better in a shortage.

This disruption we're in now is pretty severe though...don't think there's ever been anything like it.
 
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its not really about the naplex.. its more about patients

I've seen many stop taking their ACE I due to cough and their doctor has put them on it not for BP but for renal protection due to their diabetes.. most of these patients are newly diagnosed with diabetes.. and are usually on 2.5 mg of lisinopril.. but the cough still occurs..

I asked cuz since many stop their ACE I, an ARB has potential to do the same, but which ARB would you as a pharmacist recommend if you had a patient who could not take ACE I and NO BP problem ????
Telmisartan study has been conducted but many of the ARB's have been out alot longer. Being on the market longer has its advantage of becoming a generic faster, and that since Losartan, Valsartan etc have been on the market, they may be on formulary for a brand copay instead of Tier 3 or 4 or a Prior Auth Medication.

I was also asking because this week I had one patient who for the past two months has been coughing, and was given tussinex, albut inhaler and a corticosteriod inhaler .. doctor states he is coughing due to some kinda bronchitis/asthma (with no other symptoms but dry hacking cough).. and now his throat is inflammed, coughing still, has a "viral" infection says his MD, can barely talk, and yet the doctor says he should continue his corticosteriod inhaler, it will help him breath..
 
I have read the articles that have been coming out in the past year about how ACEI is the way to go for renal protection... and there is one or two on the clincial trial of Telmisartan is equal to lisinopril in renal protection..

I guess time will tell as more articles and trials are coming out for diabetes and renal protection
 
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