Why do anticholinergics cause hypotension?

[anbuitachi]

Advertisement - Members don't see this ad

So a side affect is hypotension for anticholinergics. I'm not understanding the mechanism to this... since cholinergics cause hypotension too. Can someone provide an explanation. Thanks!

 

[iamfrench]

I think there are 2 big reasons (probably other mechanisms as well):
ganglionic blockade -> blocked sympathetic reflexes for postural changes (orthostatic hypotension)
cholinergic block at the adrenal medulla -> decreased NE, Epi outflow

 

[anbuitachi]

I think there are 2 big reasons (probably other mechanisms as well):
ganglionic blockade -> blocked sympathetic reflexes for postural changes (orthostatic hypotension)
cholinergic block at the adrenal medulla -> decreased NE, Epi outflow

thanks!

 

[CaptainSSO]

I think there are 2 big reasons (probably other mechanisms as well):
ganglionic blockade -> blocked sympathetic reflexes for postural changes (orthostatic hypotension)
cholinergic block at the adrenal medulla -> decreased NE, Epi outflow

Only for the ganglion nicotinic ACh blocking agents like trimethophan and hexamethonium.