Why does KATP channel excessive functioning result in type 2 diabetes?

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UWorld #1009: Shouldn't this be type 1 diabetes? Since if KATP channel functioning all the time=>decreased insulin secretion? Isn't type 2 diabetes due to increased resistance to insulin vs. not enough secretion?

 

[Choo]

UWorld #1009: Shouldn't this be type 1 diabetes? Since if KATP channel functioning all the time=>decreased insulin secretion? Isn't type 2 diabetes due to increased resistance to insulin vs. not enough secretion?

There are three main causes of type 2 diabetes: insulin resistance, impaired secretion, and elevated glucose production.

Type 1 is complete or nearly complete insulin deficiency usually due to antibodies to beta cells.

 

[FIREitUP]

UWorld #1009: Shouldn't this be type 1 diabetes? Since if KATP channel functioning all the time=>decreased insulin secretion? Isn't type 2 diabetes due to increased resistance to insulin vs. not enough secretion?

i think this is due to beta cell exhaustion; at a certain point the beta cells can't keep up with demand since blood glucose is consistently high (thus constantly having the KATP channel constantly functioning), causing amyloid deposition in the islets and beta cell dysfunction.