Why don't we give iron in anemia of chronic disease?

[osprey099]

Is iron absolutely contraindicated in anemia of chronic disease or do you not give it cause it won't resolve anything? Could someone explain? Thank you in advanced!

---

Members don't see this ad.

 

[Yung Kelso]

When you are in a chronic disease state, levels of Hepcidin will be high. Hepcidin is a key regulator of serum Iron levels. When high, it causes iron to be sequestered into macrophages, so that pathogens cannot access it. So I imagine, any Iron you add will not improve the anemia, because it too will be sequestered into the macrophages. You have to first, resolve the underlying condition, which will lower Hepcidin levels, which then allows the iron to be used in Heme synthesis.

 

[Redpancreas]

Is iron absolutely contraindicated in anemia of chronic disease or do you not give it cause it won't resolve anything? Could someone explain? Thank you in advanced!

Someone is missing out on Pathoma.


Sent from my iPhone using SDN mobile