Why is hypophosphatemia a risk factor for pseudogout?
Started by Maxilla54
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Usually high phosphate levels can cause hypocalcemia due to negatively charged phosphate ions binding to positively charged Calcium ions. I'd imagine the opposite is also true. Hypercalcemia in turns can drive formation of more CPPD.
Would have to mean calcium pyrophosphate is more likely to precipitate out in the setting of lower serum phosphate.
HY for USMLE are hereditary hemochromatosis and primary hyperparathyroidism as risk factors for pseudogout.
Pseudogout can present as an OA-like presentation in someone with either of the above conditions - i.e., you get an x-ray of the hands showing DIP involvement in someone with Bronze diabetes --> pseudogout, not OA. Or you'll just get a monoarthritis of a large joint such as the knee.
Risk factors for pseudogout such as hypothyroidism and Wilson disease I haven't seen across any NBME material.
