Why is there diarrhea in Zollinger-Ellison Syndrome ?

[georgeissa7]

Why is there diarrhea in Zollinger-Ellison Syndrome ?

thx in advance

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[ERPCT]

osmotic diarrhea. more gastric secretions= more pancreatic secretions= more water in the bowel=diarrhea.

 

[MrBigglesworth]

acid destroys pancreatic digestive enzymes like lipase. food (like fats) doesn't get digested.. POOP

 

[Akarat]

From CURRENT Medical Diagnosis & Treatment 2013:

Gastric acid hypersecretion can cause direct intestinal mucosal injury and pancreatic enzyme inactivation, resulting in diarrhea, steatorrhea, and weight loss; nasogastric aspiration of stomach acid stops the diarrhea.

 

[iliketurt1es]

Just learned this in class... we were told that excess acid --> bile salts precipitate out --> when bile salts reach the colon, they cause efflux of water

 

[georgeissa7]

acid destroys pancreatic digestive enzymes like lipase. food (like fats) doesn't get digested.. POOP

thx but i guess this is the explanation of Steatorrhea, not watery diarrhea ..

 

[georgeissa7]

Just learned this in class... we were told that excess acid --> bile salts precipitate out --> when bile salts reach the colon, they cause efflux of water