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why...?

Discussion in 'Step I' started by goodies, May 6, 2007.

  1. goodies

    goodies Member 7+ Year Member

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    Oct 8, 2005
    NY
    i have a couple of questions... can anyone explain please?

    why does hypercalcemia lead to peptic ulcers?

    does apoptosis, necrosis, and/or atrophy occur with menses?
     
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  3. AmoryBlaine

    AmoryBlaine the last tycoon 7+ Year Member

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    May 1, 2006
    God's will.
     
  4. SkylineMD

    SkylineMD Senior Member 7+ Year Member

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    Jul 27, 2005
    from what Goljan has to say, the uterus undergoes both hypertrophy and hyperplasia so makes sense if during menses that both apoptosis and atrophy are occurring. Though on a test if given the choice between the two, i would go with atrophy as that's usually the classification its placed under.
     
  5. JayneCobb

    JayneCobb big damn hero.... Moderator Emeritus 5+ Year Member

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    Oct 17, 2006

    [SIZE=-1]prolonged hypercalcemia tends to cause high gastrin levels which increases acid secretion.
    [/SIZE]
     
  6. goodies

    goodies Member 7+ Year Member

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    Oct 8, 2005
    NY
    for some reason, kaplan says that necrosis occurs with menses.......
     
  7. SeventhSon

    SeventhSon SIMMER DOWN 7+ Year Member

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    Aug 23, 2005
    San Diego
    MDApps:
    why would high ca increase gastrin levels?

    the only thing I could think of was that more serum calcium means Ca entering voltage-gated Ca channels -> more Ach release -> more m3 stimulation of G-cells -> more gastrin release.

    the problem is that if i'm not mistaken, hypercalcemia also systemically suppresses neuronal activity (that's why you get neurological sx right). Anyone help?
     
  8. Doc 2b

    Doc 2b 5+ Year Member

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    May 19, 2004
    [​IMG]


    I think this will help.
     
  9. SeventhSon

    SeventhSon SIMMER DOWN 7+ Year Member

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    Aug 23, 2005
    San Diego
    MDApps:
    out of curiosity, what book is that? I looked in a bunch of different books and nowhere did i see gastrin as a stimulant for calcitonin secretion or Ca as a stimulant for gastrin secretion. Are both secondary effects?
     
  10. SoCuteMD

    SoCuteMD 10+ Year Member

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    Nov 28, 2005
    No more rounding!
    Also, parathyroid adenoma and pancreatic adenoma are both components of MEN I. So you'll have hypercalcemia and possibly a hx of peptic ulcers.
     
  11. Doc 2b

    Doc 2b 5+ Year Member

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    May 19, 2004
    Found it thru google. Same pic was in my notes from last year, I remember my prof saying something about how "that's why people get addicted to rolaids. they put calcium in them to keep you using them" that's the way I've always remembered it. ;) So Cute's right about the MEN sd, that will also give you an elevated gastrin even in the absence of a gastrinoma.
     

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