USC2003 said:
For those of you who are interested the Laska, Sunshine et al. 1986 study showed that the peak analgesic effect of Ibuprofen was at the 400mg dose. Above this dose has no real effect on increasing analgesia, just the length of duration. When I prescribe Ibuprofen I usually use the 600mg q 6h dose rather than the 800mg dose. No need to place more work on the liver than needed, even if you are only prescibing for a short duration. Anytime you prescribe medication you should aim to start with the minimum effective dose rather than starting with the max dose.
USC 2003 thanks for the good dialogue.
I looked at the study you listed and at least from the abstract I'm not sure it supports your position that 400mg yields the peak analgesic effect. The way I read it, and I'll admit I'm no chi-square kind of guy, they found "that increased ibuprofen serum levels lead to increased analgesia" but (possibly due to the different formulations of 400, 600, and 800 mg tablets) a larger dose did not necessarily lead to increased serum levels. This seems to be more a problem with the specific formulations or brand they used not an indication that 400 mg yields the peak analgesic effect. It also showed that at 1,2, and 3 hours 800mg produced better analgesia than 400 or 600mg at least as I read it but I yield to you since you've seen the whole article:
"Serum levels at 1, 2, and 3 hours correlated significantly with the log dose of ibuprofen (r = 0.35, 0.49, and 0.48, respectively) and with global analgesic response as measured by the percentage of the sum of the pain intensity scores (r = 0.28, 0.34, and 0.26, respectively)"
Also this study only looked at pain intensity for 6 hours post op. If your patients only hurt for 6 hours post extraction I'm coming to watch you work one day next week.
A good deal of the post extraction pain is the result of inflammation produced by the trauma to the local tissues. A higher dose of ibuprofen will yield a greater anti-inflammatory effect and IMHO less pain.
Lastly I agree that the lowest effective dose of any medicine should be used. But we're not talking about morphine here. For the typical 2-5 days of dental pain I'm comfortable with a high dose of ibuprofen because the side effects are low and the severity of the side effects are low. Also if the 600mg dose doesn't keep them comfortable it will take more medicine to get their pain reduced than if they'd taken 800mg to start with. i.e. it's easier to keep a patient comfortable than get them comfortable again after breakthough pain.
No right or wrong on this one I think. Just what you're comfortable with clincally.
JMHO
Rob