Zofran ODT absorption route

[TheTruckGuy]

Can one of y'all help me out? I had a pharmacist friend a long time ago tell me that there's practically no difference between the different zofran formulations as even the ODT requires you to swallow the saliva for it to enter systemic circulation. He pulled something up at the time to show me. Recently I had that challenged, and all I can find are a few papers stating that you do get sublingual/buccal absorption with the ODT and faster peak systemic concerntration. Asked a pharmacist I work with and she didn't know.

Is the truth a combination of GI and sublingual absorption?

Thanks

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[RxPreceptor]

Lexicomp:
"Absorption: Oral: 100%; nonlinear absorption occurs with increasing oral doses; Zofran ODT tablets are bioequivalent to Zofran tablets; absorption does not occur via oral mucosa"

More like an optimized dose form for those with nausea/vomiting (also liquid is used somewhat freq. in pediatrics too) for obvious difficulties simply getting the medication down. No dose conversions listed anywhere in the monogram

 

[owlegrad]

Anyone know about the films?

 

[BidingMyTime]

Anyone know about the films?

their are ondansetron films? Never heard of them.

I see doctors write all the time for SL Zofran, but I never could figure out why, it's a PO med.

 

[PharmDminus]

Can one of y'all help me out? I had a pharmacist friend a long time ago tell me that there's practically no difference between the different zofran formulations as even the ODT requires you to swallow the saliva for it to enter systemic circulation. He pulled something up at the time to show me. Recently I had that challenged, and all I can find are a few papers stating that you do get sublingual/buccal absorption with the ODT and faster peak systemic concerntration. Asked a pharmacist I work with and she didn't know.

Is the truth a combination of GI and sublingual absorption?

Thanks

ive always wondered this too. its an important distinction because i have heard pharmacists explain to patients that the benefit of the ODT is that if you do end up vomiting you dont need to worry about whether the zofran was absorbed or not

 

[VA Hopeful Dr]

their are ondansetron films? Never heard of them.

I see doctors write all the time for SL Zofran, but I never could figure out why, it's a PO med.

Placebo effect of not swallowing a pill.

 

[owlegrad]

their are ondansetron films? Never heard of them.

I see doctors write all the time for SL Zofran, but I never could figure out why, it's a PO med.

Zuplenz or something like that.

 

[Lnsean]

Zuplenz or something like that.

No way any plan is covering that bs...I'm guessing that's reserved for like chemo or something

 

[moose10]

If they are bio equivalent between dosage forms can you technically interchange them without prescriber consultation? Alot of times ODT is not covered and I usually call and document to change it...

 

[RxPreceptor]

Lexicomp again (Re: SL Film):
"
Film, Oral:

Zuplenz: 4 mg (1 ea [DSC], 10 ea [DSC], 30 ea); 8 mg (1 ea [DSC], 10 ea [DSC], 30 ea)"

No longer made, never seen in practice, probably has no advantage whatsoever. No generic yet, but future possibility this could return from the depths of hell one day as yet another waste of shelf space, "me too" depending on cost of course

 

[TheTruckGuy]

their are ondansetron films? Never heard of them.

I see doctors write all the time for SL Zofran, but I never could figure out why, it's a PO med.

Placebo effect for sure. But also, if someone's really nauseated having to swallow a pill with water may push them over the edge.

And then in those kids that are old enough to hold a pill in their mouth, but not quite old enough to swallow, it's just easier to give them 1/2 an ODT than get the liquid out.

 

[PA_dud3]

Do they still make the promethazine that you rub onto your wrists? I remember taking that stuff when I was younger when I had really bad nausea.

 

[Rouelle]

Do they still make the promethazine that you rub onto your wrists? I remember taking that stuff when I was younger when I had really bad nausea.

It’s a compound

 

[sakigt]

If you have to swallow a pill you usually need water, but if youre nauseated swallowing anything can be nasty and cause you to throw up.

So the ODT exists so you can take the medicine without liquid.