Ondansetron tablet crushed vs ondansetron ODT

[storyhill2]

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If both are given SL is there a difference in how they are metabolized? I understand ODT is absorbed in the floor of the mouth so it bypasses the liver metabolism but wouldn't this also happen with a crushed ondansetron tablet put under tongue?

 

[Sakonji]

My knowledge is very shaky on this topic, but I don't think your saliva can break down something that is formulated to withstand your stomach's acid, unless you have a way of removing all that expedient stuff (which you can't do with just simple grinding)

 

[deleted205891]

neither is approved for SL use, both are to be given orally.

 

[Pronounce Doxazosin]

neither is approved for SL use, both are to be given orally.

This
Both the regular tabs and the ODT are absorbed through the GI tract

 

[storyhill]

Thanks for your input. I was mistaken in my understanding after reading this article.

https://www.ijddr.in/drug-development/sublingual-route-for-the-systemic-delivery-of-ondansetron.pdf

Do you think this is referring to the ondansetron SL film product and not the ODT? Thanks for the correction.