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I had a question regarding muscle relaxants and effects in neuro disease. I understand that in nerve injury (decrease ACh release), you get upregulation of ACh receptors causing increase sensitivity to Sux and decrease sensitivity to nondepol. The opposite is true in cases where you have decrease ACh Receptors (Myasthenia Gravis). I am doing some reading and Morgan and Mikhail has Lambert Eaten Syn (decrease Ach?) as increase sensitivity to BOTH sux and nondepol. For ALS they say increased sensitivity to nondep, which seems contrary to what you'd expect (decrease ACh release -->upregulation ACh R's-->decrease sens to nondep). Can anyone make sense out of this?