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I realize this may be a stupid question for some people, but I'm having a hard time understanding it.
What I'm confused about is with Bl groups O & AB:
If O has no antigens but it has antibodies to A and to B, then it can't receive blood from anyone other than Bl group O because it'll agglutinate (since O has antibodies against the other blood groups). But how can it be a universal donor if it has antibodies against the other antigens?? I realize that it doesn't have antigens but how can it be given to the other blood groups when it possesses antibodies against both A & B?? Won't it agglutinate?
Same with Bl group AB - if it has no antibodies, but has antigens A & B, then how is it a universal recipient - when you give Bl group A to a person who has Bl group AB, then won't the anti-B antibodies in Bl group A cause agglutination (since AB has the B antigen)?
Also, another question is what type of antibodies are these? I was searching on SDN, and from what I understand, all the antibodies are IgM with the exception of bl group O which makes IgG antibodies to A & B which can cross the placenta. Yet Wikipedia says Bl group O "contains IgM antibodies against both A and B antigens." ??
What I'm confused about is with Bl groups O & AB:
If O has no antigens but it has antibodies to A and to B, then it can't receive blood from anyone other than Bl group O because it'll agglutinate (since O has antibodies against the other blood groups). But how can it be a universal donor if it has antibodies against the other antigens?? I realize that it doesn't have antigens but how can it be given to the other blood groups when it possesses antibodies against both A & B?? Won't it agglutinate?
Same with Bl group AB - if it has no antibodies, but has antigens A & B, then how is it a universal recipient - when you give Bl group A to a person who has Bl group AB, then won't the anti-B antibodies in Bl group A cause agglutination (since AB has the B antigen)?
Also, another question is what type of antibodies are these? I was searching on SDN, and from what I understand, all the antibodies are IgM with the exception of bl group O which makes IgG antibodies to A & B which can cross the placenta. Yet Wikipedia says Bl group O "contains IgM antibodies against both A and B antigens." ??