Step I ACE Inhibitors causing Proteinuria

[username456789]

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P. 474 (I think, I'm going from memory) talks about ACE inhibitors and mentions proteinuria as a side effect. Considering the fact that they're often used to MINIMIZE proteinuria in diabetics, I was wondering if anyone knew what the mechanism was for actually causing proteinuria. I certainly don't remember covering that during the school year.

 

[kryptik]

i always thought it was a typo, acei prevent proteinuria

 

[PokerDoc]

in the DIT errata it says 'change to "proteinuria prevention"

 

[username456789]

Ah, thanks, should've bothered to look there.

 

[Abdul Salam]

Reversible after stopping captopril in most but not all cases ,an SH-group related autoimmune(vascular)reaction

 

[Abdul Salam]

I think it related to high dose of captopril

 

[theTruth_97]

how exactly does an ACE inhibitor prevent proteinuria?

 

[dfib slim]

how exactly does an ACE inhibitor prevent proteinuria?

I'd guess decreased ATII-->efferent arteriole vasodilation-->decreased glomerular hyperfiltration-->decreased proteinuria

 

[theTruth_97]

I'd guess decreased ATII-->efferent arteriole vasodilation-->decreased glomerular hyperfiltration-->decreased proteinuria

haha oh that makes sense lol. its amazing how simple some explanations can be yet we make them out to be these complicated things in our brains

 

[dfib slim]

haha oh that makes sense lol. its amazing how simple some explanations can be yet we make them out to be these complicated things in our brains

Yeah, don't let UWorld train you into over thinking on the real deal.