Hi, I have a problem with understanding why in organic chemistry species with a negative charge are called bases and species with positive one - acids, whereas in biology texts positive charge refers to basicity and negative charge to acidity. For example, from Wade 6th ed, Organic Chemistry: "An acetylide ion is a strong base and a powerful nucleophile". R-C≡C:- Also, an amine group is referred to as a basic group, because it has a pair of lone electrons on nitrogen. At the same time in biology texts phosphates in DNA are referred to as acidic (even though they have negative charge), and histones are referred to as basic (positive charge). I thought that a base is an electron donor, and therefore it should have a negative charge before reaction with acid. Do you have any idea how to distinguish between acids and bases with regard to their charges? Thank you in advance!