the problem with pharmacy is that there is no cost-of-living adjustment. look at the BLS stats...a pharmacist in florida vs new york makes the same money, even though new york state as a whole is way more expensive place to live. if anything, you sacrifice pay to live in the larger cities, which IMO is mainly a lifestyle choice (but also where the majority of jobs are)
also, i'd rather buy a 500k 2 bed in SD and risk an earthquake/ridiculous tax increases than have to deal with mosquitoes, hurricanes, rick scott, george zimmerman, crappy schools, etc. maybe i'm just biased.
a myth? I think you have it wrong. i'm pretty sure mortgage INTEREST tax deduction is the #1 reason why people itemize each year (which lets them add on more deductions such as property tax deduction, charitable donations, and etc). you failed to calculate the interest/year on 450k, even at 350 basis points this exceeds single standard deduction by a lot.
of course you shouldnt buy a house just because it's a tax deduction. but it's definitely not a myth.