Step I aldosterone escape

[MudPhud20XX]

Advertisement - Members don't see this ad

FA mentions "aldosterone escape" in
1. Atrial natriuretic peptide: Dilates afferent renal arterioles and constricts efferent arterioles, promoting diuresis and contributing to "aldosterone escape" mechanism.

2. Primary Hyperaldosteronism:
Caused by adrenal hyperplasia or an aldosterone-secreting adrenal adenoma (Conn syndrome), resulting in hypertension, hypokalemia, metabolic alkalosis, and low plasma renin. Normal Na+ due to "aldosterone escape" = no edema due to aldosterone escape mechanism. May be bilateral or unilateral.

Can anyone please explain "aldosterone escape" in these two contexts?

Many thanks in advance.

 

[tasar1898]

Well even though your alderstone is maximal , the Increased Blood Volume leads to Sodium/H2O diuresis via 1) ANP/BNP , 2) Reduced Renin and AT2 , 3) Increased GFR , so even though you are reabsorbing at the collecting ducts , losses from PCT can compensate and you get Sodium at the high normal range and NO edema