Yeah, that's a real tough one. It's very hard not to get involved in their drama, so exercise caution. You already are doing the right thing by choosing not to enable her. Generally they won't hear a word you are saying in regard to their habits because to do so would be to face into their addictions. It's really best when they come to you, but letting them know that you care can be helpful. If you feel into the situation and you think it'll help (because most addicts aren't really interested in your feedback; they focus on denial), however, you could try gently confronting her with something like, "I notice that you are taking quite a lot of pills everyday, I feel _____, and have a thought it seems to be not serving you. Is everything okay, are you doing okay?" Obviously, you need to check into what words seem appropriate. If she gets all defensive, then you should probably back off and leave her with, "I'm available if you should ever want to talk." If she asks for help, I'd recommend sending her to AA, they are very experienced at dealing with addictions of any sort. Be careful of her trying to drag you into her addictive patterns; know when to let it go if it comes to that.