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@hushcom, how effective is an upward trend for students who had 'rough starts' academically? And is, let's say a 3.7-4.0 GPA in the last 3+ yrs of schooling enough to make up for a poor start that may have taken place 5-7 years ago?
If you survive the screen an upward trend is quite effective. We know that a lot of people have to adjust to college, and it's very common for people with decent freshman GPAs to struggle a bit during sophomore year. The key is that at some point you need to demonstrate that you can handle the academic rigor of med school. I have seen people get Bs and Cs in their prereqs during the first two years of college and load the last two years with fluff. That sort of upward trend is not very convincing.