Polymyositis (endomyseal inflammation) vs Dermatomyositis (perifascicular).
http://emedicine.medscape.com/article/1170205-workup#a0723
http://emedicine.medscape.com/article/1170205-workup#a0723
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Step I Another First aid error....
Started by fahimaz7
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About polymyositis: "The endomysial infiltrates are mostly in foci in the fascicles"
About dermatomyositis: "dermatomyositis is the only disease that shows perifascicular atrophy"
Are we reading the same link?
Remember this by PE4. Polymysositis = endomysial infiltrates = CD4 mediated. "The other one is the other one."
Edit: I annotated this into my 2010 FA from Goljan and UWorld and don't own a 2011 copy to compare. Maybe they added the info to 2011 incorrectly? Either way, your first sentence seems correct (I'm assuming that's from FA) based on the link you provided.
About dermatomyositis: "dermatomyositis is the only disease that shows perifascicular atrophy"
Are we reading the same link?
Remember this by PE4. Polymysositis = endomysial infiltrates = CD4 mediated. "The other one is the other one."
Edit: I annotated this into my 2010 FA from Goljan and UWorld and don't own a 2011 copy to compare. Maybe they added the info to 2011 incorrectly? Either way, your first sentence seems correct (I'm assuming that's from FA) based on the link you provided.
Just had UWorld say that both are involved. Macs and CD4 are first, and CD8 comes in later on and destroys the muscle cells via MHC-I mechanisms.
Polymyositis that is.
Should have added, disclaimer: a year ago when I annotated this from UWorld into my FA, it said endomysial = polymyositis = CD4. Still, this is (far) above the level of difficulty present on the actual Step 1, it would seem.
