Aortic Regurg

[aspiringmd1015]

in aortic regurg, you have a widened pulse pressure, and the diastolic pressure decreases

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[SBR249]

is there supposed to be a question in there?

If you are asking about why you have a widened pulse pressure and lower diastolic pressure, it's because of the fact that blood flows back into the LV during diastole. The backward flow decreases the pressure for forward flow during diastole which decreases diastolic pressure.

The widened pulse pressure is due to 2 factors 1) the lower diastolic pressure (see above) and 2) the increased end-diastolic LV volume due to the backflow during diastole which according to Frank-Starling law causes increased contractility and stroke volume which means greater systolic pressure

 

[mcloaf]

...yes?

 

[cruCiATE]

The heart is filling more due to the back up of blood, so the Left Ventricular Systolic Volume is going to increase, Widening your Pulse Pressure, and causing the head bobbing and bounding pulses every time the heart is contracting.

 

[aspiringmd1015]

oh damn, i accidentaly edited the post, i wrote the question down somewhere ill write it again. My bad guys

 

[aspiringmd1015]

cant find it, believe it was something to do with this, the diastolic pressure is associated with the TPR of the systemic circuit correct? so how does the TPR correlate with the decreased diastolic volume of blood entering the systemic circuit effect the TPR? are they correlated?

 

[cruCiATE]

Its very good actually to correlate TPR with End Diastolic Volume (ie. Diastolic bp) and CO with End Systolic Volume
(ie. Systolic bp), and understanding the hemodynamics behind MAP: TPR x CO, having this facilitates greatly when answering Cardio pharm

 

[aspiringmd1015]

i thought the EDV was associated with preload->cardiac output(mostly associated with stroke volume) and therefore systoloic bp

 

[cruCiATE]

EDV = Preload thats right, but EDV is determined by your Venous Return which is directly affected by the TPR (remember the Cardiovascular system its a parallel Circuit with different type of resistance within each separate organ system that will ultimately affect the blood volume returning to the heart ie. EDV/Preload), on the other hand the Cardiac Output is going to be affected by the afterload as well as Stroke Volume and Heart Rate.

 

[aspiringmd1015]

lower the tpr, increased q(flow) into the venous system and thus increased venous return and increased EDV?

 

[aspiringmd1015]

lol ****, im still not clear on the concept. Will try to go back and read it again, if anyone can also paint the entire picture concisely that'd be helpful too, thanks

 

[Psai]

decreased diastolic volume means lower pressure in the vessel which increases sympathetic tone so tpr should go up

problem here is not anything with the venous system but the blood that goes into the aorta comes back because the aortic valve is crappy so your end diastolic volume is increased compare to normal because blood gets pushed out of the heart but some of it comes back in from the aorta