This is very much my department.
These are essentially amphetamine derivatives (grossly, as that is eliminates all subtlety). Most of the so called "bath salts" (also sold as iPhone cleaner, Jewelry cleaner, plant food and more) are substituted on the phenyl ring and have a significant amount of serotonin agonism. Some of the newer ones have more substitution of the amine side and show more epinephrine/dopamine agonism.
We have been recommended aggressive benzodiazepine therapy with small doses of barbs as a back up. These patients can often take anesthesia sized doses without too much difficulty. Propofol would probably also work, however I'd prefer not to use it as monotherapy. There may be a role for haloperidol in the truly psychotic patient but I would absolutely not use it as monotherapy and I'd only add it after I'd given a few rounds of large doses benzos.
The potpourri stuff is basically crap potpourri that has been laced with synthetic cannabinoid agonists. These drugs are potent agonists, unlike THC which is actually a mixed agonist/antagonist. The new bad boy, AM-2201, seems to have a higher incidence of seizure, when compared to the older ones (which have been banned), like JWH-018. The patient frequently present psychotic with a significantly sympathomimetic picture. Treatment is the same...benzo, benzo, benzo.
