I'm in biochemistry right now--my impressions of it (as I'm studying for a final coming up very, very soon) is that much of the material overlaps, so it may be useful to make connections with material that you have been seeing throughout the course. That way, even with the large amount of material that you have to learn, you will find that things will make sense as you learn to integrate things together.
Also, do problems--as many as you can get your hands on. I can't remember who said this on SDN, but I remember reading in a forum post that exam questions tend to be converted from one form or another rather than created or destroyed (sorry to whomever said this--but thank you!). There will be things that you'll find are guaranteed to show up on an exam in some way, and doing problems/going over old exams will give you some idea of what might be tested.
To answer your question, OP--yes, it does come down to studying, as it takes a while to memorize, process things, and make connections. But it will help give you an edge, if anything.