Bio Kidneys

[Jps17kl]

---

Members do not see this ad.

Can someone please explain the filtrate concentration through the nephron in detail? I feel like every book is saying something different about proximal and distal convoluted tubules.

All I know is at the
Bowmans capsule receives everything but RBC and proteins
Descending loop of henle: water flows out so filtrate becomes more concentrated
Acscending loop of henle: salts flow out so filtrate becomes less concentrated

Thank you in advance

 

[Xo1991]

One of the most important things is that the primary function of the proximal convoluted tubule is reabsorption of substances that the body needs, like glucose. Also osmolarity is highest at the renal medulla because ions are exiting the ascending loop. Then, in the collecting duct, water is reabsorbed via aquaporins, which are activated by ADH (aka vasopressin) from the posterior pituitary

 

[Jps17kl]

One of the most important things is that the primary function of the proximal convoluted tubule is reabsorption of substances that the body needs, like glucose. Also osmolarity is highest at the renal medulla because ions are exiting the ascending loop. Then, in the collecting duct, water is reabsorbed via aquaporins, which are activated by ADH (aka vasopressin) from the posterior pituitary

Thank you so much for that.

What happens in the distal convoluted tubules then?

 

[Illfavor]

Thank you so much for that.

What happens in the distal convoluted tubules then?

Secretion of salt, water and bicarbonate ions, regulation of potassium intake.

It's here that aldosterone acts to increase uptake of sodium and water as well, increasing blood pressure/volume. If I had to know one thing about the distal tubule for the DAT, that would be it.

 

[Jps17kl]

Secretion of salt, water and bicarbonate ions, regulation of potassium intake.

It's here that aldosterone acts to increase uptake of sodium and water as well, increasing blood pressure/volume. If I had to know one thing about the distal tubule for the DAT, that would be it.

Thank you,
Secretion, meaning it is being added to the filtrate right?

 

[Illfavor]

Sorry for the confusion, the lumen of the tubule is losing salt/water, etc and gaining potassium.

 

[Jps17kl]

Sorry for the confusion, the lumen of the tubule is losing salt/water, etc and gaining potassium.

So,
Bowman's capsule: glucose, salts, vitamins, urea (everything except large proteins and RBC) into the filtrate

Proximal tubule: glucose, amino acid, vitamin, mineral, water out of tubule(reabsorption)

Dec Loop of Henle: passive flow of water out of tubule

Asc Loop of Henle: active and passive transport of salts out of tubule

Distal tubule: salt, water out of tubule, K into tubule

collecting duct: water out of tubule.

I feel so stupid, sorry for so many questions haha.

Then where does secretion come into play? Cliffsnotes litss prox/distal tubules as secretion...

 

[Illfavor]

So,
Bowman's capsule: glucose, salts, vitamins, urea (everything except large proteins and RBC) into the filtrate

Proximal tubule: glucose, amino acid, vitamin, mineral, water out of tubule(reabsorption) H+ and Ammonia are secreted into the tubule.

Dec Loop of Henle: passive flow of water out of tubule

Asc Loop of Henle: active and passive transport of salts out of tubule

Distal tubule: salt, water out of tubule, K and H+into tubule

collecting duct: water out of tubule. NaCl and Urea also diffuse out

I feel so stupid, sorry for so many questions haha.

Then where does secretion come into play? Cliffsnotes litss prox/distal tubules as secretion...

What you have to understand is that things flow out of the lumen AND are secreted into the lumen. I edited your thing to reflect that. So many salts leave the lumen because the inner and outer medulla need to maintain a high osmolarity. This is needed for the countercurrent exchange; this keeps water flowing out of the distal tubule/collecting duct and concentrates the urine.