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[Glycogen]

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what is the primary intracellular buffer?

a.TRIS
b.phosphate
c.bicarbonate
d.CO2
e.NAD+

Please explain your reasoning,and if it is possible tell me in what type of reaction we use this buffer (this is actually what I don't know).
Thanks.

 

[Danny289]

what is the primary intracellular buffer?

a.TRIS
b.phosphate
c.bicarbonate
d.CO2
e.NAD+

Please explain your reasoning,and if it is possible tell me in what type of reaction we use this buffer (this is actually what I don't know).
Thanks.

answer is red and Bicarbonate in plasma outside of cell.

 

[Glycogen]

hey,Danny.I was wonder in what kind of reaction it will be used?
Have any idea?
I could not find it on wiki.Bicarbonate obviously will be use in the blood!!!!???

 

[Danny289]

hey,Danny.I was wonder in what kind of reaction it will be used?
Have any idea?
I could not find it on wiki.Bicarbonate obviously will be use in the blood!!!!???

as i said Bicarbonate (HCO3-) is in plasma and it can be with Na+ making the salt and buffer. inside the cell H2Po4- can be with K+ because the cocentration of those cations inside and outside. maybe I am wrong but it is my guess.

 

[PooyaH]

Isn't biocarbonate used in duodenum (small instestine)?

 

[topdent1]

The phosphate buffer is the most abundant buffer system intracellular. I don't have a super geeky explanation. What makes sense to me is that the body uses phosphates for energy and other purposes beyond me. As a result, a buffer that consists of phosphates must be implemented to control the pH of the intracellular fluid. Anyone have a more scientific explanation?

 

[HoangDDS]

what is the primary intracellular buffer?

a.TRIS
b.phosphate
c.bicarbonate
d.CO2
e.NAD+

Please explain your reasoning,and if it is possible tell me in what type of reaction we use this buffer (this is actually what I don't know).
Thanks.

Main elements are H2PO4- and HPO4 2- . HP04 2-, picks up the H+ from some strong acid and becomes H2PO4 - . And H2PO4- buffers OH- .

The phosphate buffer sys. is involved in buffering renal tubular fluid and intracellular fluids.

 

[HoangDDS]

Oh, and bicarbonate is the main buffer for extracellular fluid. Used in the kidney and the lungs.

 

[osimsDDS]

phosphate buffer is intracellular while bicarbonate is extracellular...usually blood carries CO2 in the form of HCO3-Na+ so thats a buffer system for extracellular...

 

[hdu]

It is the equillibrium in human fluids:

H2PO4-(aq)<-----> H+(aq) + HPO42-(aq)

These species are particularly abundant in the intracellular fluid (the concentration in blood is not significant in terms of pH regulation)

How it works:

The medium becomes acidic? the reaction goes to the left for decreasing the acidity

the medium is becoming basic and protons are consumed? the reaction goes to the right to increases free H+


and:

Ka = [H +] [HPO42-] /[H2PO4-]

if we do the math at physiological conditions, we can calculate that the pka is around 7

As buffers are very effective regulating the pH around the value of pK (+ 1 pH unit), Phosphate buffer is perfect for regulating the intracellular pH

I hope it helps

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