Biochem Proteins and Structures

[752779]

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Hey Guys, I have not taken Biochem yet, however I can manage to eliminate the choices down to 50%. Can anyone explain why R8D substitution replaces a positive charged residue with a negatively charged residue?
How can one recognize that R8D is a positive or a negative charged residue?
How come K4R is not has no role in substitution?

Thanks

 

[popopopop]

R = arginine (positive), 8 = position, D = aspartic acid (negative)

 

[752779]

R = arginine (positive), 8 = position, D = aspartic acid (negative)

Thanks so much!

 

[aldol16]

If you have not taken biochem, the first thing you should memorize (yes, I am saying memorize here because there is no way around it even though I am very strongly against memorizing material for the MCAT) are the amino acid properties, 3- and 1-letter codes, and structures. These are very high yield on the MCAT and you must know these.

 

[Mr. otcoD]

I agree completely! You need to know the general ideas of each and every one of them. Such as "Can this amino acid be phosphorylated?"
Even pKa/how pH affects the ionic charge of them. But First, you gotta know what they look like which will help. Watch these videos 8 times (im not kidding.) Draw out each one until you got the hang of it.

 

[752779]

I agree completely! You need to know the general ideas of each and every one of them. Such as "Can this amino acid be phosphorylated?"
Even pKa/how pH affects the ionic charge of them. But First, you gotta know what they look like which will help. Watch these videos 8 times (im not kidding.) Draw out each one until you got the hang of it.

Thanks so much!