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Relationship b/w cooperativity/allostery and entropy

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internaldebris

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Hi SDN!

I was wondering what the relationship between cooperativity and entropy is with regards to hemoglobin and oxygen binding.

I came across a question in TPR biochem review on this topic and in the answer description it says "consistent with the 'cooperativity' phenomenon of each of these binding events, it is likely that each binding event increases overall disorder of the tetramer association reaction incrementally."

but based on what is in that sentence, wouldn't each binding event decrease overall disorder, thus entropy? is this referring to the structural changes within Hb that occur with each binding event, and THIS is the entropy/disorder they are referring to?
 

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