PyruvateDehydrogenase is activated by AcetylCoA and NADH.NADH occurs during hig energy in the cell and acetylCoA is during less energy.Please explain.thanks
Pyruvate dehydrogenase complex is an enzyme that converts pyruvate ( end product of aerobic glycolysis) to acetyl co A to provide substrate for citric acid cycle or if energy levels are higher then this acetyl co A enters fatty acid synthesis( storage). Pyruavte dehydrogenase is stimulated by insulin, amp,phosphoenolpyruvate and is competitively inhibited by nadh, acetyl co and atp. Acetyl CO A occurs in a cell when there is ample amount of energy and thus goes into citric acid cycle to further enter into electron transport chain. If there is still more energy then the body signals to send the acetyl co a into fatty acid synthesis to convert this excess energy into storage form. Incase of low energy state and there is lack of availability of dietary glucose then glycogen breakdown happens( glycogenolysis or gluconeogenesis).Fatty acid stores are broken down yeilding acetyl co a which enters tca cycle to yeild energy eventually. I dont believe acetyl co a nor nadh activate pyruvate dehydrogenase complex. This is in brief, i hope it makes sense.
