Does anyone know a good set of materials to learn blood clotting? Any suggestions?
blood clotting---help
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Are you refering to the clotting cascade?
If so I would think just drawing it over and over again and then add in what happens if each factor/component is defective. I haven't done Hem at school but did summer research/clinical stuff in the field and that is what the doctors I worked with recommended for when I hit the hem unit this year.
If so I would think just drawing it over and over again and then add in what happens if each factor/component is defective. I haven't done Hem at school but did summer research/clinical stuff in the field and that is what the doctors I worked with recommended for when I hit the hem unit this year.
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12, 11, 9, 8, 10, 5, 2, 1 (and 7 off to the side for extrinsic). 2, 7, 9, 10, C, S are vitamin K dependent. That's about it.
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THE WALL: a story of survival within the blood vessel. by Tobias Fish (originally posted at action studios)
Veinola was a prosperous township that had along the length of its borders a wall that many a tavern-goer would boast over pints to be impenetrable. Within the wall lived two factions of builders, the extrinsics and the intrinsics, who maintained a constant watch over the wall and its surrounding areas. The intrinsics were a land dwelling people who lived near the fertile plots immediately adjacent to the wall, while the extrinsics were river inhabitants, who occupied the banks of the RED RIVER just beyond the realm of the intrinsics. Despite their differences, both groups were inherently peaceful and neither maintained an aggressive military, a principle which was a reflection of their touchstone maxim that defense is the best offense. But all was not as it seemed in the outwardly simple township, for the two groups were partners in a great secret that was both the key to their prosperity and an ever present danger.
All was well in the village until one day there was a darkening in the sky. The change was sudden, and people only had a moment to look up before a jagged flaming meteor burst forth from the stygian clouds and arched on a collision path for the city. Luckily for the villagers however, the meteor dipped low in its trajectory, and instead of crossing into the city, impacted into the illustrious wall. The collision put forth a large amount of tissue factor smoke, released from the damaged endothelial mortar of the wall, which wafted over to the RED RIVER—the dwelling place of the Extrinsics.
Factor septimus (VII), a vigilant sentry of the Extrinsics, was the first to notice the acrid TF smell.
‘Something is amiss,' he whispered to himself and with haste, he donned his white, calcified, bone armour (VIIa), painted his face with a phospholipid war grease, ate an avocado for nourishing VITAMIN K and swam off to the village centre to alert the town commander.
Meanwhile, in the land of the Intrinsics, the damage had hit much closer to home. The meteor had caused severe damage to the wall, exposing the collagen backbone of the structure. Hageman the XII, a menial service worker in charge of monitoring the wall for damage, noticed the exposed charged backbone with his charge sensing magnet and immediately went on alert. Yet, because he was only an apprentice and living in the strict and hierarchal society of the intrinsics, he was not allowed to do anything about the damage except notify his superiors. So, Hageman went to his boss, Factor XI, who was in turn alerted, and went to his boss Factor IX. Factor IX, who was co-chair of the intrinsic society for defence of the wall, could make no move without the other co-chair Factor octavius (VIII). Therefore, Factor IX went over to Factor VIII's office and after a brief conference, they both agreed that the situation was critical. Thus, similar to Factor septimus of the extrinsics, they doned their calcium bone armour, ate avocados for vitamin K, painted their faces with a phospholipid war grease, and—holding hands—headed for the village center to alert the town commander.
They joined up with Factor VII who was had just finished his swim and together they went in to see the commander, Factor Decimus(X).
‘Factor Septimus! Why, I can smell an acrid TF smell all about you, and I see that you have engaged in active duty by donning your armour! Oh, and Factor IXa and VIIIa, you both look equally perturbed. Something must be wrong at the wall,' Factor Decimus (X) said before either party could say anything. He was a seasoned commander and could read his men's faces without hesitation.
‘We must act quickly,' Decimus said with a grave look on his face, before also donning his calcified bone armour, painting his face with phospholipid war grease, and sending an alarm to all the other factor VII sentries who in turn went and alerted more factor X commanders.
‘Men,' Factor Decimus said in a rousing speech, ‘The situation is critical, and we must act accordingly. WE must activate the prothrombin wall building mason robot—the secret to our impenetrable defence. I understand the consequences of such an action and that if we were to lose control of the prothrombin robot, it could doom us all by building unnecessary walls across our river. But the wall has been damaged and you all understand that I do not make this decision lightly'
With these words, Factor Decimus, looking stoic in his calcified bone armour and phospholipid war grease, went to his key master Factor Quintus (Va) who gave him the key for the lock on the chains of the prothrombin mason robot. Decimus then released the robot from its bondage, thereby converting it to the active THROMBIN robot.. The thrombin robot immediately flew down to the river and started baking large amounts of the liquidy reddish FIBRINOGEN substance in its furnace, converting it to FIBRINOGEN. This it used as a building material to patch up the broken wall.
The robot was a tireless machine but could but the damage proved too extensive for it alone, and so it called upon the professional masons of Veinola, the PLATELETS. The platelets came running quickly along, changed their SHAPE by extruding a great number of GpIIb/IIIa rock-climbing hooks to themselves which they used to ADHERE and AGGREGATE to the fibrinogen scaffold the robot had put in place. From this vantage point they were able to SECRETE the calcified bone armour so many of the Extrinsic and Intrinsic Factors required as well as summon more of their platelet commrades.
Their work was tiresome and so they took regular brakes to eat steak sandwiches, full of ARACHIDONIC ACID. They also signaled Hageman that the job was not done and more THROMBIN robots needed to be activated by EXPOSING NEGATIVE CHARGES which Hageman detected with his charge sensing magnet.
And so, more Intrinsic Factors and THROMBIN robots were activated until the damaged to the wall was managed. When the work was done a number of surveyors such as ANTITHROMBIN III who went around and told all the Extrinsics, and Intrinsics to stand down, PLASMIN who cleaned up any excess FIBRIN that the thrombin robot had left scattered about, And TFPI (tissue factor pathway inhibitor) whose job it was to clean up the TF smoke from the atmosphere and bring things back to normal.
Veinola was a prosperous township that had along the length of its borders a wall that many a tavern-goer would boast over pints to be impenetrable. Within the wall lived two factions of builders, the extrinsics and the intrinsics, who maintained a constant watch over the wall and its surrounding areas. The intrinsics were a land dwelling people who lived near the fertile plots immediately adjacent to the wall, while the extrinsics were river inhabitants, who occupied the banks of the RED RIVER just beyond the realm of the intrinsics. Despite their differences, both groups were inherently peaceful and neither maintained an aggressive military, a principle which was a reflection of their touchstone maxim that defense is the best offense. But all was not as it seemed in the outwardly simple township, for the two groups were partners in a great secret that was both the key to their prosperity and an ever present danger.
All was well in the village until one day there was a darkening in the sky. The change was sudden, and people only had a moment to look up before a jagged flaming meteor burst forth from the stygian clouds and arched on a collision path for the city. Luckily for the villagers however, the meteor dipped low in its trajectory, and instead of crossing into the city, impacted into the illustrious wall. The collision put forth a large amount of tissue factor smoke, released from the damaged endothelial mortar of the wall, which wafted over to the RED RIVER—the dwelling place of the Extrinsics.
Factor septimus (VII), a vigilant sentry of the Extrinsics, was the first to notice the acrid TF smell.
‘Something is amiss,' he whispered to himself and with haste, he donned his white, calcified, bone armour (VIIa), painted his face with a phospholipid war grease, ate an avocado for nourishing VITAMIN K and swam off to the village centre to alert the town commander.
Meanwhile, in the land of the Intrinsics, the damage had hit much closer to home. The meteor had caused severe damage to the wall, exposing the collagen backbone of the structure. Hageman the XII, a menial service worker in charge of monitoring the wall for damage, noticed the exposed charged backbone with his charge sensing magnet and immediately went on alert. Yet, because he was only an apprentice and living in the strict and hierarchal society of the intrinsics, he was not allowed to do anything about the damage except notify his superiors. So, Hageman went to his boss, Factor XI, who was in turn alerted, and went to his boss Factor IX. Factor IX, who was co-chair of the intrinsic society for defence of the wall, could make no move without the other co-chair Factor octavius (VIII). Therefore, Factor IX went over to Factor VIII's office and after a brief conference, they both agreed that the situation was critical. Thus, similar to Factor septimus of the extrinsics, they doned their calcium bone armour, ate avocados for vitamin K, painted their faces with a phospholipid war grease, and—holding hands—headed for the village center to alert the town commander.
They joined up with Factor VII who was had just finished his swim and together they went in to see the commander, Factor Decimus(X).
‘Factor Septimus! Why, I can smell an acrid TF smell all about you, and I see that you have engaged in active duty by donning your armour! Oh, and Factor IXa and VIIIa, you both look equally perturbed. Something must be wrong at the wall,' Factor Decimus (X) said before either party could say anything. He was a seasoned commander and could read his men's faces without hesitation.
‘We must act quickly,' Decimus said with a grave look on his face, before also donning his calcified bone armour, painting his face with phospholipid war grease, and sending an alarm to all the other factor VII sentries who in turn went and alerted more factor X commanders.
‘Men,' Factor Decimus said in a rousing speech, ‘The situation is critical, and we must act accordingly. WE must activate the prothrombin wall building mason robot—the secret to our impenetrable defence. I understand the consequences of such an action and that if we were to lose control of the prothrombin robot, it could doom us all by building unnecessary walls across our river. But the wall has been damaged and you all understand that I do not make this decision lightly'
With these words, Factor Decimus, looking stoic in his calcified bone armour and phospholipid war grease, went to his key master Factor Quintus (Va) who gave him the key for the lock on the chains of the prothrombin mason robot. Decimus then released the robot from its bondage, thereby converting it to the active THROMBIN robot.. The thrombin robot immediately flew down to the river and started baking large amounts of the liquidy reddish FIBRINOGEN substance in its furnace, converting it to FIBRINOGEN. This it used as a building material to patch up the broken wall.
The robot was a tireless machine but could but the damage proved too extensive for it alone, and so it called upon the professional masons of Veinola, the PLATELETS. The platelets came running quickly along, changed their SHAPE by extruding a great number of GpIIb/IIIa rock-climbing hooks to themselves which they used to ADHERE and AGGREGATE to the fibrinogen scaffold the robot had put in place. From this vantage point they were able to SECRETE the calcified bone armour so many of the Extrinsic and Intrinsic Factors required as well as summon more of their platelet commrades.
Their work was tiresome and so they took regular brakes to eat steak sandwiches, full of ARACHIDONIC ACID. They also signaled Hageman that the job was not done and more THROMBIN robots needed to be activated by EXPOSING NEGATIVE CHARGES which Hageman detected with his charge sensing magnet.
And so, more Intrinsic Factors and THROMBIN robots were activated until the damaged to the wall was managed. When the work was done a number of surveyors such as ANTITHROMBIN III who went around and told all the Extrinsics, and Intrinsics to stand down, PLASMIN who cleaned up any excess FIBRIN that the thrombin robot had left scattered about, And TFPI (tissue factor pathway inhibitor) whose job it was to clean up the TF smoke from the atmosphere and bring things back to normal.
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Glorious.
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Just find a picture of it. Stare, then draw draw draw draw draw. After ten or so blind attempts you'll start putting it together. I think drawing is super high yield with stuff that can all be represented visually on one page of a text like that.
