Bowditch effect

[NewYorkCity11]

A high heart rate (pacemaker-induced) produces a small increase in contractility (Bowditch effect). Because Ca2+ enters the cell more rapidly than it is sequestered by the sarcoplasmic reticulum, intracellular Ca2+ increases. So why it is not affect duration of 3 phase of cardiac potential? More calcium--> more positive charge inside-->more time required for 3 (K out) phase to make resting potential. Thank you.

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[Catalystik]

A high heart rate (pacemaker-induced) produces a small increase in contractility (Bowditch effect). Because Ca2+ enters the cell more rapidly than it is sequestered by the sarcoplasmic reticulum, intracellular Ca2+ increases. So why it is not affect duration of 3 phase of cardiac potential? More calcium--> more positive charge inside-->more time required for 3 (K out) phase to make resting potential. Thank you.

Your posting history shows a consistent pattern of asking for homework help. This is not SDN's purpose and is the reason why a previous thread was locked.

Also, if you are a premed, you are expected to post in the premed forum, not the medical student forum. Thank you.

 

[Winged Scapula]

Exactly. SDN discourages help with school work as it extinguishes independent thought and at times, can approach offering medical advice for more clinical questions. Since this is your second warning in less than 1 week for the same, I trust it will not happen again

Closing.