Calcium levels with metastatic breast cancer

[ijn]

I am having a problem with this concept. So metastatic breast cancer to the bone can cause both blastic and lytic lesions. Let's say you have a female breast cancer patient with increased uptake in the bone on an imaging scan. What would their calcium, phosphate, and PTH levels be?

Also, what would the levels of those three substances be for a metastatic prostate cancer?

Thanks!

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[Convalaria]

I am having a problem with this concept. So metastatic breast cancer to the bone can cause both blastic and lytic lesions. Let's say you have a female breast cancer patient with increased uptake in the bone on an imaging scan. What would their calcium, phosphate, and PTH levels be?

Also, what would the levels of those three substances be for a metastatic prostate cancer?

Thanks!

Metastatic calcifications differ from dystrophic because metastatic ones are always due to increased Ca and/or phosphate.

Osteoblastic metastases (prostate cancer) deal with direct bone destruction, that causes high alkaline phosphatase -> reactive bone formation. So I guess, elevated Ca, elevated phosphate and decreased PTH.

Osteolytic mts - when tumor produces substances that activate osteolysis, i.e. IL-1, PTH-related peptide (squamous cell carcinoma in lungs, renal cell carcinoma).
If high PTHrp: elevated Ca, decreased phosphate


Breast cancer can do both


Edit:
I might be wrong,look what i found http://www.orthobullets.com/pathology/8045/metastatic-cancer-of-bone

 

[ijn]

For some reason I have it in my head that osteoblastic lesions cause hypocalcemia, hypophosphatemia, and high reactive PTH since you're increasing bone formation. Are you really just forming osteoid without mineralization? And those activated osteoblasts are concurrently activating osteoclasts thus resulting in hypercalcemia?

 

[Convalaria]

article describing osteolytic and osteoblastic mechanisms

 

[Convalaria]

For some reason I have it in my head that osteoblastic lesions cause hypocalcemia, hypophosphatemia, and high reactive PTH since you're increasing bone formation. Are you really just forming osteoid without mineralization? And those activated osteoblasts are concurrently activating osteoclasts thus resulting in hypercalcemia?

You're right, osteoblasts consume calcium and phosphate to form bone, this is the reason why lesions are radiodense. So increased consumption of these minerals would lead to hypocalcemia and hypophosphatemia.

And in osteolytic: it's hypercalcemia and hypophosphatemia (due to PTHrp that uses the same receptors as PTH ) and low PTH (because negative fb from Ca), that's why bones with mts are lucent.

 

[AdvinCharles]

Hey, i am sorry but i can't say anything about this because right now i am not having knowledge about it, if i will find something then i will surely tell you.

 

[AndyRSC]

Cool story, bro.

 

[VisionaryTics]

Hey, i am sorry but i can't say anything about this because right now i am not having knowledge about it, if i will find something then i will surely tell you.

Thanks for checking in.

Post of the century.

 

[ishockk]

Hey, i am sorry but i can't say anything about this because right now i am not having knowledge about it, if i will find something then i will surely tell you.

Did you find something yet?

 

[placeboconspiracy]

Did you find something yet?

That guy was last seen on SDN 6 years+ ago.

 

[ishockk]

Ye mate .. just toying around

That guy was last seen on SDN 6 years+ ago.